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Thursday, May 14, 2020
4:00 PM - 5:00 PM
Noyes 153 (J. Holmes Sturdivant Lecture Hall)

Frontiers in Chemical Biology Seminar

Translating RNA Sequence Into Lead Small Molecule Medicines
Matthew Disney, Professor, Department of Chemistry, The Scripps Research Institute - Florida,
Speaker's Bio:
Matthew Disney is a Professor in the Departments of Chemistry and Neuroscience at The Scripps Research Institute’s Florida campus. For the past 12 years, his research efforts have been focused exclusively on developing approaches to drug RNA with small molecules. He has pioneered synergistic computational and experimental approaches to tackle this difficult molecular recognition problem by developing Inforna, an approach that identifies druggable RNAs and small molecules to target them via sequence-based design. He has also developed target validation approaches that allow one to identify target RNAs and binding sites within them by crosslinking small molecule RNAs in cells. These approaches have been broadly leveraged to target RNAs in many disease settings. Prof. Disney’s professional accolades include the NIH Director’s Pioneer Award, the Tetrahedron Young Investigator Award, and the Raymond and Beverly Sackler International Prize in the Physical Sciences, among numerous others.

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